Sultans managed to set the mammoth target at a loss of only two wickets, after the sensational performance of captain Muhammad Rizwan, who scored a ton during the innings and stayed on the pitch throughout the innings.
Earlier, Karachi Kings had won the toss and opted to bowl first against Multan Sultans.
Multan are currently at the top of the points table with six points after four games. Karachi are placed in fourth position with two points after four matches.
Shan Masood, Mohammad Rizwan (wk/c), Rilee Rossouw, David Miller, Kieron Pollard, Khushdil Shah, Carlos Brathwaite, Usama Mir, Abbas Afridi, Ihsanullah, Mohammad Ilyas.
James Vince, Haider Ali, Matthew Wade(w), Irfan Niaz Khan, Shoaib Malik, Imad Wasim(c), Ben Cutting, Aamer Yamin, Akif Javed, Muhammad Umar, Imran Tahir